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Proceedings Paper

Effect of light-activated tin ethyl etiopurpurin (SnET2) on normal rabbit choriocapillaries
Author(s): Gholam A. Peyman; Darius M. Moshfeghi; Andrew Moshfeghi; Bahram Khoobehi; Daniel R. Doiron; David H. Crean
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Paper Abstract

The aim of this study was to investigate the use of photodynamic therapy (PDT) using tin ethyl etiopurpurin (SnET2) for occluding the choriocapillaris in the eyes of pigmented rabbits. Following intravenous injection of SnET2 (0.5 and 1.0 mg/kg) or lipid emulsion alone, the fundus of pigmented rabbits was irradiated within 5 - 15 minutes of photosensitizer injection using 664 nm light at a fluence of 300 mW/cm2 and light doses of 5 - 20 J/cm2. Fundoscopy, fluorescein angiography (FA), and histology were performed at 1, 14 and 28 days after PDT. Following PDT, closure of choriocapillaris was achieved with light doses as low as 5 J/cm2 (17 seconds). Control eyes of rabbits demonstrated no effect to light irradiation at the parameters tested. PDT with SnET2 was effective in this animal model using low levels of activating light for the treatment of choriocapillaris.

Paper Details

Date Published: 17 May 1996
PDF: 8 pages
Proc. SPIE 2673, Ophthalmic Technologies VI, (17 May 1996); doi: 10.1117/12.240061
Show Author Affiliations
Gholam A. Peyman, Louisiana State Univ. Eye Ctr. (United States)
Darius M. Moshfeghi, Louisiana State Univ. Eye Ctr. (United States)
Andrew Moshfeghi, Louisiana State Univ. Eye Ctr. (United States)
Bahram Khoobehi, Louisiana State Univ. Eye Ctr. (United States)
Daniel R. Doiron, PDT, Inc. (United States)
David H. Crean, PDT, Inc. (United States)


Published in SPIE Proceedings Vol. 2673:
Ophthalmic Technologies VI
Jean-Marie A. Parel; Karen Margaret Joos; Pascal O. Rol, Editor(s)

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