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Proceedings Paper

Usefulness of fluorescence photodetection of neoplastic urothelial foci in bladder cancer following intravesical instillation of delta-aminolevulinic acid (5-ALA)
Author(s): Patrice Jichlinski; Martin Forrer; Jerome C. Mizeret; Daniel Braichotte; Georges A. Wagnieres; Georges Zimmer; Louis Guillou; Franz R. Schmidlin; Peter Graber; Hubert van den Bergh; Hans-Juerg Leisinger
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Paper Abstract

An excellent knowledge of histopathological risk factors of superficial bladder transitional cell carcinoma is mandatory to establish the prognosis of the disease. Presence or absence of carcinoma in situ (CIS) in superficial bladder cancer is one of the most powerful risk indicators. This study examines the usefulness of fluorescence photodetection of neoplastic urothelial foci in bladder cancer following intravesical instillation of delta-aminolevulinic acid (5-ALA). Following bladder instillation of an aqueous solution of 5-ALA in 43 cases, a Krypton ion laser and a Xenon arc-lamp were successively used as excitation source of the PPIX fluorescence. Tissular samples were respectively taken during bladder wall photodetection, either by the means of a video camera, or under direct endoscopic observation. A good correlation was observed between the fluorescence findings and the histopathological diagnosis. On a total of 298 biopsies, 49/110 carcinomatous lesions were detected by the fluorescence, whose more than 36% were CIS. PPIX induced fluorescence with topical bladder instillation of 5-ALA is an efficient and useful method of mapping the mucosa in bladder carcinoma. Moreover, in case of a multifocal disease, this method seems very helpful in finding and treating any residual malignant spots at the end of a transurethral bladder resection.

Paper Details

Date Published: 17 May 1996
PDF: 8 pages
Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); doi: 10.1117/12.240028
Show Author Affiliations
Patrice Jichlinski, CHUV Hospital/Univ. of Lausanne (Switzerland)
Martin Forrer, Swiss Federal Institute of Technology (Switzerland)
Jerome C. Mizeret, Swiss Federal Institute of Technology (Switzerland)
Daniel Braichotte, Swiss Federal Institute of Technology (Switzerland)
Georges A. Wagnieres, Swiss Federal Institute of Technology (Switzerland)
Georges Zimmer, Institute of Pathology/Univ. of Lausanne (Switzerland)
Louis Guillou, Institute of Pathology/Univ. of Lausanne (Switzerland)
Franz R. Schmidlin, CHUG Hospital/Univ. of Geneva (Switzerland)
Peter Graber, CHUG Hospital/Univ. of Geneva (Switzerland)
Hubert van den Bergh, Swiss Federal Institute of Technology (Switzerland)
Hans-Juerg Leisinger, CHUV Hospital/Univ. of Lausanne (Switzerland)


Published in SPIE Proceedings Vol. 2671:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI
C. Thomas Vangsness; Kenneth Eugene Bartels; Lawrence S. Bass; Graham M. Watson; R. Rox Anderson; R. Rox Anderson; Royice B. Everett; Douglas E. Ott; Reza S. Malek; Rodney A. White; Lloyd P. Tate; Aaron P. Perlmutter, Editor(s)

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