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Proceedings Paper

5-ALA assisted photodynamic therapy in canine prostates
Author(s): Ronald Sroka; Rolf Muschter M.D.; Ruth Knuechel; Pia Steinbach; Aaron P. Perlmutter M.D.; Thomas Martin; Reinhold Baumgartner
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Paper Abstract

Photodynamic therapy (PDT) and interstitial thermotherapy are well known treatment modalities in urology. The approach of this study is to combine both to achieve a selective treatment procedure for benign prostatic hyperplasia (BPH) and prostate carcinoma. Measurements of thy in-vivo pharmacokinetics of 5-ALA induced porphyrins by means of fiber assisted ratiofluorometry showed a maximum fluorescence intensity at time intervals of 3 - 4 h post administration. Fluorescence microscopy at that time showed bright fluorescence in epithelial cells while in the stroma fluorescence could not be observed. Interstitial PDT using a 635-nm dye laser with an irradiation of 50 J/cm2 resulted in a nonthermic hemorrhagic lesion. The lesion size did not change significantly when an irradiation of 100 J/cm2 was used. The usefulness of PDT for treating BPH as well as prostate carcinoma has to be proven in further studies.

Paper Details

Date Published: 17 May 1996
PDF: 5 pages
Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); doi: 10.1117/12.240025
Show Author Affiliations
Ronald Sroka, Univ. of Munich (Germany)
Rolf Muschter M.D., Univ. of Munich (Germany)
Ruth Knuechel, Univ. of Regensburg (Germany)
Pia Steinbach, Univ. of Regensburg (Germany)
Aaron P. Perlmutter M.D., New York Hospital (United States)
Thomas Martin, New York Hospital (United States)
Reinhold Baumgartner, Univ. of Munich (Germany)

Published in SPIE Proceedings Vol. 2671:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI
C. Thomas Vangsness M.D.; Kenneth Eugene Bartels D.V.M.; Lawrence S. Bass M.D.; Graham M. Watson M.D.; R. Rox Anderson M.D.; R. Rox Anderson M.D.; Royice B. Everett; Douglas E. Ott M.D.; Reza S. Malek M.D.; Rodney A. White M.D.; Lloyd P. Tate V.D.M.; Aaron P. Perlmutter M.D., Editor(s)

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