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Proceedings Paper

Photochemotherapy of intimal hyperplasia using Psoralen activated by uv light in porcine model
Author(s): Lisa A. Buckley; Kenton W. Gregory M.D.; Deborah T. Bahlman R.N.; HanQun Shangguan; Henner Fahrenbach; Eli Rosenthal M.D.; Peter C. Block M.D.
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Paper Abstract

Psoralen activated by UVA light (PUVA) was investigated as a means of inhibiting smooth muscle cell proliferation resulting from balloon injury. Twenty kilogram domestic swine were anesthetized and underwent balloon angioplasty to create a 133% overstretch injury. Assignments of treatment and control were randomized between the left anterior descending (LAD) and circumflex (LCX) coronaries arteries. The animals were given with 5 mg/kg of 8- methoxypsoralen eternally. Treatment vessels received 600 mJ/cm2 of 364 nm light during balloon inflation to activate the psoralen. Control vessels received drug and balloon injury only. Serum was obtained during the light delivery to assess psoralen levels. At 30 days, animals were sacrificed and the coronary arteries perfusion fixed. Five sections per vessel were analyzed morphometrically to determine percent intimal area and extent of injury. The restenosis injury index was 0.21 plus or minus .02 in treatment vessels and 0.14 plus or minus .01 in the controls with a p-value less than .02. In this large animal model of balloon angioplasty injury, psoralen activated by ultraviolet light increased intimal hyperplasia.

Paper Details

Date Published: 17 May 1996
PDF: 6 pages
Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); doi: 10.1117/12.239996
Show Author Affiliations
Lisa A. Buckley, Oregon Medical Laser Ctr. (United States)
Kenton W. Gregory M.D., Oregon Medical Laser Ctr. (United States)
Deborah T. Bahlman R.N., Oregon Medical Laser Ctr. (United States)
HanQun Shangguan, Oregon Medical Laser Ctr. (United States)
Henner Fahrenbach, Regional Primate Ctr. (United States)
Eli Rosenthal M.D., Oregon Medical Laser Ctr. (United States)
Peter C. Block M.D., Oregon Medical Laser Ctr. (United States)


Published in SPIE Proceedings Vol. 2671:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI
C. Thomas Vangsness M.D.; Kenneth Eugene Bartels D.V.M.; Lawrence S. Bass M.D.; Graham M. Watson M.D.; R. Rox Anderson M.D.; R. Rox Anderson M.D.; Royice B. Everett; Douglas E. Ott M.D.; Reza S. Malek M.D.; Rodney A. White M.D.; Lloyd P. Tate V.D.M.; Aaron P. Perlmutter M.D., Editor(s)

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