Share Email Print
cover

Proceedings Paper

Effects of benzoporphyrin derivative monoacid on balloon-injured arteries in a swine model of restenosis
Author(s): G. Michael Vincent; Jolene Fox; Suzanne Johnson; Phillipe Maragon
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We evaluated benzoporphyrin derivative verteporfin (BPD) photodynamic therapy (PDT) and dark effect on the intima (I) and media (M) hyperplasia (H) response of swine iliac arteries to balloon dilatation (Bdil) injury. Four month old Yucatan swine received bdil at 8 ATM pressure to all four iliac arteries. Pigs were randomly assigned to groups. PDT was performed with intraluminal 690 nm, cw laser (200 milliwatts and 30 joules per cm2 tissue). Six weeks later, sites were pressure fixed, and excised at autopsy. Sections from each site were evaluated for I and M thickness, injury score (1 equals normal, 4 equals worst), and smooth muscle cell (SMC) intensity and distribution. Groups were compared using the Mann-Whitney U test. Means for each parameter were determined, and group means used for statistical analysis. Conclusions: (1) Bdil produced IH and MH. (2) PDT enhanced IH. (3) 2 mg/kg BPD reduced MH and produced a favorable trend in IH and injury. (4) No differences in SMC intensity and distribution were present.

Paper Details

Date Published: 17 May 1996
PDF: 6 pages
Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); doi: 10.1117/12.239995
Show Author Affiliations
G. Michael Vincent, LDS Hospital/Univ. of Utah School of Medicine (USA) and QLT Phototherapeutics Inc. (Canada)
Jolene Fox, LDS Hospital/Univ. of Utah School of Medicine (USA) and QLT Phototherapeutics Inc. (Canada)
Suzanne Johnson, LDS Hospital/Univ. of Utah School of Medicine (USA) and QLT Phototherapeutics Inc. (Canada)
Phillipe Maragon, LDS Hospital/Univ. of Utah School of Medicine (USA) and QLT Phototherapeutics Inc. (Canada)


Published in SPIE Proceedings Vol. 2671:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI
C. Thomas Vangsness; Kenneth Eugene Bartels; Lawrence S. Bass; Graham M. Watson; R. Rox Anderson; R. Rox Anderson; Royice B. Everett; Douglas E. Ott; Reza S. Malek; Rodney A. White; Lloyd P. Tate; Aaron P. Perlmutter, Editor(s)

© SPIE. Terms of Use
Back to Top