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Proceedings Paper

Selective uptake of texaphyrins in atheromatous plaque
Author(s): Kathryn W. Woodburn; Stuart W. Young; Q. Fan; David Kessel; Richard A. Miller
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Paper Abstract

Texaphyrins are water soluble porphyrinoids which selectively localize in atheromatous plaque. The paramagnetic gadolinium texaphyrin is an excellent contrast agent which enables plaque detection by MRI. The diamagnetic lutetium texaphyrin, using fluorescence methods, was also shown to label atheromatous plaque. The chemical environment of bound lutetium texaphyrin within plaque was determined by fluorescence emission spectra to be predominantly lipophilic. The texaphyrin was found to bind to the lower density lipoproteins in the atherosclerotic-induced animals. Lutetium texaphyrin is an excellent candidate for photoatherolytic therapy.

Paper Details

Date Published: 17 May 1996
PDF: 10 pages
Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); doi: 10.1117/12.239994
Show Author Affiliations
Kathryn W. Woodburn, Pharmacyclics, Inc. (United States)
Stuart W. Young, Pharmacyclics, Inc. (United States)
Q. Fan, Pharmacyclics, Inc. (United States)
David Kessel, Wayne State Univ. School of Medicine (United States)
Richard A. Miller, Pharmacyclics, Inc. (United States)


Published in SPIE Proceedings Vol. 2671:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI
C. Thomas Vangsness; Kenneth Eugene Bartels; Lawrence S. Bass; Graham M. Watson; R. Rox Anderson; R. Rox Anderson; Royice B. Everett; Douglas E. Ott; Reza S. Malek; Rodney A. White; Lloyd P. Tate; Aaron P. Perlmutter, Editor(s)

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