Proceedings PaperInterferometer methods for tissue dosimetry and determination of material properties
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We propose that displacement, velocity, and double-pulse holographic interferometry can be used to measure the dynamic response of tissue to pulsed lasers. Tissue material properties and dosimetry for pulsed laser interactions with tissue can then be addressed with these tools. The present use of fiber-optic coupled interferometric devices for biomedical applications suggests that these methods can be successfully adapted for the measurement of tissue material properties such as Gruneisen parameters, total energy absorption, energy deposition profiles, characteristics of multi-dimensional stress wave propagation, and heterogeneous effects. In this paper I will show (1) how Michelson interferometry was used to in stress confinement experiments with non-biological materials to make direct measurements of the Gruneisen parameters of a complex, composite material; (2) the advantages of velocity interferometry for determination of the energy deposition profile; and (3) the use of double-pulse holographic interferometry for multi-dimensional stress wave propagation and heterogeneous effects. We will propose a fiber-optic interferometer which is uniquely adapted for in-vivo biomedical applications.