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Proceedings Paper

Laser-induced stress transients: aqueous pores of membranes
Author(s): Thomas J. Flotte M.D.; Shun Lee; Hong Zhang; Daniel J. McAuliffe Sr.; Jeremy Taitelbaum; Apostolos George Doukas
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Paper Abstract

Lasers can be used to enhance the delivery of a number of molecules. The model that best fits our data is for the formation of aqueous pores. These pores are present for up to 80 seconds. Our experiments have shown that laser-induced stress transients can be utilized as a vector for intracellular delivery of molecules that may or may not normally cross the cell membrane. These two conditions have been tested with Photofrin and DNA. This technology may have applications in cell and molecular biology, cancer therapy, gene therapy, and others.

Paper Details

Date Published: 7 May 1996
PDF: 7 pages
Proc. SPIE 2681, Laser-Tissue Interaction VII, (7 May 1996); doi: 10.1117/12.239569
Show Author Affiliations
Thomas J. Flotte M.D., Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Shun Lee, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Hong Zhang, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Daniel J. McAuliffe Sr., Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Jeremy Taitelbaum, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Apostolos George Doukas, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 2681:
Laser-Tissue Interaction VII
Steven L. Jacques, Editor(s)

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