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Proceedings Paper

Dosimetry for pulsed laser photodynamic therapy
Author(s): Brian W. Pogue; Robert W. Redmond; Tayyaba Hasan
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Paper Abstract

A photochemical dosimetric system has been developed to record the spatially resolved light dose absorbed by a photosensitizer in a tissue-simulating medium. Relative measurements from these dosimeters match theoretical calculations of the number of photons absorbed per unit volume. These dosimeters have been used to compare the relative penetration of high intensity pulsed irradiation versus continuous wave for benzoporphyrin derivative monoacid ring `a' under typical tissue irradiation conditions. Calculations and experiments indicated an increase in relative light penetration for high intensity irradiation, due to transient changes in sample absorption. The relative deposited dose of different pulse intensities has been compared with the numerical simulation.

Paper Details

Date Published: 7 May 1996
PDF: 10 pages
Proc. SPIE 2681, Laser-Tissue Interaction VII, (7 May 1996); doi: 10.1117/12.239565
Show Author Affiliations
Brian W. Pogue, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Robert W. Redmond, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Tayyaba Hasan, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 2681:
Laser-Tissue Interaction VII
Steven L. Jacques, Editor(s)

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