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Proceedings Paper

Photodynamic effect occurance in photosensitizer mixtures with albumin or blood serum, or hemoglobin and blood
Author(s): Nadezgda L. Torshina; Anna M. Posypanova; Anna I. Volkova
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Paper Abstract

Under laser irradiation of different photosensitizers (PS) mixtures with pure albumin or without hemolysis blood serum the photodynamic effect (PE) is scarcely to be manifested. The coupling of PS with albumins prevents the interactions of dissolved oxygen molecules with PS molecules and formation of active oxygen forms. In order to promote the PE it is necessary to add the solution of hemoglobin. The PE is readily recognized in mixtures of PS with the blood. Such mixing leads to the erythrocytes' destruction and yields uncombined hemoglobin in blood plasma. The irradiation of hemoglobin mixtures with PS leads to the destruction of hemoglobin. In this case the direct combination of oxygen molecules with hemoglobin is important for PE performance (the deoxy hemoglobin can not promote PE otherwise).

Paper Details

Date Published: 10 May 1996
PDF: 2 pages
Proc. SPIE 2678, Optical Diagnostics of Living Cells and Biofluids, (10 May 1996); doi: 10.1117/12.239538
Show Author Affiliations
Nadezgda L. Torshina, General Physics Institute (Russia)
Anna M. Posypanova, General Physics Institute (Russia)
Anna I. Volkova, General Physics Institute (Russia)

Published in SPIE Proceedings Vol. 2678:
Optical Diagnostics of Living Cells and Biofluids
Daniel L. Farkas; Robert C. Leif; Alexander V. Priezzhev; Toshimitsu Asakura; Bruce J. Tromberg, Editor(s)

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