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Proceedings Paper

Laser Doppler flowmetry in photodynamic therapy on xenotransplanted tumors
Author(s): Anja Vervoorts; H. Achim Rood; Joerg G. Moser; Marcus Klotz
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Paper Abstract

Perfusion of tumor tissue is a necessary prerequisite for radiotherapy and Photodynamic Tumor Therapy (PDT). For PDT perfusion means oxygen supply to a light activated photosensitizing drug inside tumor cells to destroy these cells specifically by light activated singlet oxygen. These experiments are normally done in rodents, but can be much more easily performed on tumors transplanted to the extraembryonal painfree vessels developed during chick embryogenesis. We chose the yolk sac membrane (YSM) and the chorioallantoic membrane (CAM) for quantitative blood flow measurements. Near infrared light (830 nm) was used for measurements in vascularized xenotransplanted tumors on the extraembryonal membranes because at this wavelength blood flow can be detected also in vessels covered by tumor cells. We measured the influences on blood flow of different photosensitizers with and without therapeutic irradiation and single components of a polyphasic PDT System.

Paper Details

Date Published: 10 May 1996
PDF: 7 pages
Proc. SPIE 2678, Optical Diagnostics of Living Cells and Biofluids, (10 May 1996); doi: 10.1117/12.239531
Show Author Affiliations
Anja Vervoorts, Heinrich Heine Univ. (Germany)
H. Achim Rood, Heinrich Heine Univ. (Germany)
Joerg G. Moser, Heinrich Heine Univ. (Germany)
Marcus Klotz, Klotz Analytical Registration Techniques (Germany)

Published in SPIE Proceedings Vol. 2678:
Optical Diagnostics of Living Cells and Biofluids
Daniel L. Farkas; Robert C. Leif; Alexander V. Priezzhev; Toshimitsu Asakura; Bruce J. Tromberg, Editor(s)

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