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Proceedings Paper

Diagnosis of inflammatory rheumatic diseases with photon density waves
Author(s): Juergen Beuthan; Viravuth Prapavat; Rolf-Dieter Naber; Olaf Minet; Gerhard J. Mueller
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Paper Abstract

Rheumatoid arthritis (RA) is a common inflammatory disease of interphalangeal joints. The utilization of conventional imaging systems (e.g. x-rays) for non invasive diagnostics at an early stage of the disease is difficult, since pathologically induced changes do not occur at this stage in hard tissue. Use of MR and ultrasound methods are both methodically problematic and expensive. Therefore investigations for optical diagnostics using photon density waves (PDW) were carried out. The PDW was realized with an intensity modulated laser diode (825 nm, fmod: 110 MHz) and an ac- and phase detection in a 2D transillumination scanner. Measurements of optical properties of synovia and synovialis of healthy and early RA stages were performed and indicated a significant pathological increase of (mu) s. The detected PDW-pictures provided corresponding results. Further investigations regarding the object- variation of the modulation transfer function provide a sufficient spatial resolution in order to assign functional changes to anatomical structures. The results are presented using photos.

Paper Details

Date Published: 24 April 1996
PDF: 11 pages
Proc. SPIE 2676, Biomedical Sensing, Imaging, and Tracking Technologies I, (24 April 1996); doi: 10.1117/12.238824
Show Author Affiliations
Juergen Beuthan, Freie Univ. Berlin (Germany)
Viravuth Prapavat, Freie Univ. Berlin (Germany)
Rolf-Dieter Naber, Freie Univ. Berlin (Germany)
Olaf Minet, Freie Univ. Berlin (Germany)
Gerhard J. Mueller, Freie Univ. Berlin (Germany)

Published in SPIE Proceedings Vol. 2676:
Biomedical Sensing, Imaging, and Tracking Technologies I
Robert A. Lieberman; Halina Podbielska M.D.; Tuan Vo-Dinh, Editor(s)

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