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Proceedings Paper

System for fast measurement of in-vivo tissue fluorescence spectra under multiple wavelength excitations
Author(s): Haishan Zeng; Calum E. MacAulay; Branko Palcic
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Paper Abstract

Tissue autofluorescence properties are excitation wavelength dependent. In this work, we developed a nitrogen dye laser -- OMA system capable of quickly measuring tissue autofluorescence spectra in vivo under multiple wavelength excitation. The system consists of a nitrogen dye laser with stepper motor for wavelength selection, an OMA with gated intensified detector, and a PC computer. A bifurcated fiber optic bundle is used to conduct the excitation laser light and to collect the fluorescence light. Gating electronics are used to achieve a high signal to noise ratio, allowing fluorescence measurements to be performed with ambient light on or under white light illumination during endoscopy. Excitation wavelength changes are performed automatically and quickly by the stepper motor which is controlled by the OMA PIA port. The system has been tested with a tissue phantom. The time needed to switch from one excitation wavelength to the next excitation wavelength is about one second.

Paper Details

Date Published: 24 April 1996
PDF: 5 pages
Proc. SPIE 2676, Biomedical Sensing, Imaging, and Tracking Technologies I, (24 April 1996); doi: 10.1117/12.238815
Show Author Affiliations
Haishan Zeng, British Columbia Cancer Ctr. (Canada)
Calum E. MacAulay, British Columbia Cancer Ctr. (Canada)
Branko Palcic, British Columbia Cancer Ctr. (Canada)


Published in SPIE Proceedings Vol. 2676:
Biomedical Sensing, Imaging, and Tracking Technologies I
Robert A. Lieberman; Halina Podbielska; Tuan Vo-Dinh, Editor(s)

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