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Proceedings Paper

Three-dimensional x-ray imaging of the anatomy and function of the lungs and pulmonary arteries in dogs following single lung transplant
Author(s): Qing-Hua Wu; Christopher G. A. McGregor; Xue-Si Wu; Mauro Rinaldi; Folke N. Nilsson; Henry D. Tazelaar; Erik Leo Ritman
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Paper Abstract

It was the goal of this study to see if relatively noninvasive CT studies could provide a quantitative index of acute lung rejection in single lung transplantation. Using volume scanning fast CT, the change in cross-sectional area of the major pulmonary arteries from systole to diastole, regional lung perfusion and ventilation was measured in 12 dogs with left lung allotransplantation before and during rejection and four dogs with left lung autotransplantation. All dogs were anesthetized and scanned in a fast computed tomography scanner (dynamic spatial reconstructor--DSR) during several ventilatory cycles and again during injection of contrast medium into the right atrium. There was significant reduction of regional air content, ventilation, perfusion and pulmonary artery compliance during rejection of the transplanted lung. The severity of these changes related linearly with the histological indices of rejection. It is concluded that minimally invasive dynamic CT imaging of transplanted lung can be used to detect acute rejection and its severity.

Paper Details

Date Published: 8 April 1996
PDF: 8 pages
Proc. SPIE 2709, Medical Imaging 1996: Physiology and Function from Multidimensional Images, (8 April 1996); doi: 10.1117/12.237897
Show Author Affiliations
Qing-Hua Wu, Beijing Anzhen Hospital (China)
Christopher G. A. McGregor, Mayo Clinic and Foundation (United States)
Xue-Si Wu, Beijing Anzhen Hospital (China)
Mauro Rinaldi, IRCCS Policlinico S. Matteo (Italy)
Folke N. Nilsson, Sahlgrens Hospital (Sweden)
Henry D. Tazelaar, Mayo Clinic and Foundation (United States)
Erik Leo Ritman, Mayo Clinic and Foundation (United States)

Published in SPIE Proceedings Vol. 2709:
Medical Imaging 1996: Physiology and Function from Multidimensional Images
Eric A. Hoffman, Editor(s)

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