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Proceedings Paper

Acute effects of delayed reperfusion following myocardial infarction: a 3D x-ray imaging analysis
Author(s): Robert D. Simari; M. R. Bell; Y. C. Pao; B. J. Gersh; Erik Leo Ritman M.D.
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Paper Abstract

Clinical and experimental data suggest that delayed reperfusion of the infarct related artery may limit infarct expansion without increasing myocardial salvage. In order to assess the potential mechanisms involved, an acute closed chest canine model of myocardial infarction and delayed reperfusion was studied. Nineteen dogs underwent 3D computed tomography in the Dynamic Spatial Reconstructor (a fast, volume imaging, CT scanner) at baseline and three and four hours later to estimate left ventricular chamber volumes, global distensibility and regional myocardial stiffness. A control group was scanned without intervention. An occlusion group underwent four hours of coronary artery occlusion. A reperfusion group underwent three hours of coronary artery occlusion followed by one hour of reperfusion. Similar infarct sizes were seen in the occlusion and reperfusion groups. Globally reperfusion was associated with increased left ventricular end diastolic pressure and prolongation of global relaxation. Regionally reperfusion was associated with increased myocardial stiffness, intramyocardial blood volume and wall thickness within the infarct zone relative to the not reperfused myocardium.

Paper Details

Date Published: 8 April 1996
PDF: 10 pages
Proc. SPIE 2709, Medical Imaging 1996: Physiology and Function from Multidimensional Images, (8 April 1996); doi: 10.1117/12.237880
Show Author Affiliations
Robert D. Simari, Mayo Clinic and Foundation (United States)
M. R. Bell, Mayo Clinic and Foundation (United States)
Y. C. Pao, Univ. of Nebraska (United States)
B. J. Gersh, Georgetown Univ. (United States)
Erik Leo Ritman M.D., Mayo Clinic and Foundation (United States)

Published in SPIE Proceedings Vol. 2709:
Medical Imaging 1996: Physiology and Function from Multidimensional Images
Eric A. Hoffman, Editor(s)

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