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Proceedings Paper

Protein database searching with MSn spectra of polypeptides
Author(s): Jimmy K. Eng; John R. Yates
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Paper Abstract

Database searching with tandem mass spectra has been demonstrated as a powerful method to correlate peptides and proteins to gene sequences for identification. In this study preliminary data is shown for extending the cross-correlation database searching method to multi-stage mass spectra of polypeptides. This method may provide a means to directly identify large polypeptides or proteins without the necessity of proteolytic hydrolysis to produce peptides amenable to tandem mass spectrometry.

Paper Details

Date Published: 1 April 1996
PDF: 5 pages
Proc. SPIE 2680, Ultrasensitive Biochemical Diagnostics, (1 April 1996); doi: 10.1117/12.237626
Show Author Affiliations
Jimmy K. Eng, Univ. of Washington (United States)
John R. Yates, Univ. of Washington (United States)


Published in SPIE Proceedings Vol. 2680:
Ultrasensitive Biochemical Diagnostics
Gerald E. Cohn; Steven A. Soper; C. H. Winston Chen, Editor(s)

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