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Proceedings Paper

Excimer v. Nd:YAG: comparative analysis of initial ultrastructural alterations produced by two distinct lasers
Author(s): Alexey J. Nevorotin
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Paper Abstract

Fine structural alteratious produced iediate1y after irradiation with either XeC1 excimer or Nd:Y.AG laser have been studied in rat liver samples processed histochemically for glucose-6-phosphatase (GP) activity, a marker enzyme for the endoplasmic reticulum (ER) of hepatocytes. General vesiculation of ER along with moderate inactivation of GP was apparent following excimer lazing which contrasted with better structural but poorer enzymatic preservation of ER in the hepatocytes irradiated with Nd:YAG laser. c'i the basis of this and our recent study. (A. Nevorotin, M. Kul 1 . 1989. Arch. Pathol . v. 51, N 7, pp. 63'TO ) a conclus ion is drawn on a potential surgical advantage of excimer laser over its Nd:YAG counterpart due presumably to lesser extent of cellular and macromolecular damage implicative in the process of healing of laser-inflicted lesions. A mechanism of ER vesiculation is considered in the iignt of probable dynamic impact transferred to the ER membranes by excimer irradiation by analogy with other nign energy mechanical forces (e.g. nign gravitation or ultrasonication) known to interfere with membrane structural organization.

Paper Details

Date Published: 1 September 1990
PDF: 11 pages
Proc. SPIE 1353, First International Conference on Lasers and Medicine, (1 September 1990); doi: 10.1117/12.23761
Show Author Affiliations
Alexey J. Nevorotin, Tartu Univ. (Russia)

Published in SPIE Proceedings Vol. 1353:
First International Conference on Lasers and Medicine
Vitali I. Konov; Gerhard J. Mueller; Alexander M. Prokhorov, Editor(s)

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