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Proceedings Paper

Laser-induced fluorescence detection of dysplasia in Barrett's esophagus
Author(s): Masoud Panjehpour; Bergein F. Overholt M.D.; Tuan Vo-Dinh; Donna H. Edwards; Paul F. Buckley III; Joseph F. DeCosta; Rodger C. Haggitt M.D.
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Paper Abstract

A study was conducted to determine whether laser-induced fluorescence could detect high grade dysplasia in Barrett's esophagus. Four-hundred-ten nm laser light was used to induce autofluorescence of Barrett's mucosa in 36 patients during routine endoscopy. The spectra were analyzed using the Differential Normalized Fluorescence (DNF) Index technique to differentiate high grade dysplasia from either low grade or non-dysplastic mucosa. Each spectrum was classified as either premalignant or benign using two different DNF indices. Analyzing the fluorescence spectra from all patients using one DNF Index, 96% of non- dysplastic Barrett's samples classified as benign tissue. All low grade dysplasia samples classified as benign. Ninety percent of high grade dysplasia samples classified as premalignant. Twenty-eight percent of mixed low grade/focal high grade dysplasia samples classified as premalignant. In summary, high grade dysplasia in Barrett's esophagus patients can be detected by endoscopic laser-induced fluorescence spectroscopy using differential normalized fluorescence technique.

Paper Details

Date Published: 5 April 1996
PDF: 10 pages
Proc. SPIE 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy, (5 April 1996); doi: 10.1117/12.237584
Show Author Affiliations
Masoud Panjehpour, Thompson Cancer Survival Ctr. (United States)
Bergein F. Overholt M.D., Thompson Cancer Survival Ctr. (United States)
Tuan Vo-Dinh, Oak Ridge National Lab. (United States)
Donna H. Edwards, Thompson Cancer Survival Ctr. (United States)
Paul F. Buckley III, Thompson Cancer Survival Ctr. (United States)
Joseph F. DeCosta, Thompson Cancer Survival Ctr. (United States)
Rodger C. Haggitt M.D., Univ. of Washington Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 2679:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy
Robert R. Alfano; Abraham Katzir, Editor(s)

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