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Proceedings Paper

Selective synthesis and characterization of chlorins as sensitizers for photodynamic therapy
Author(s): Franz-Peter Montforts; Dirk Kusch; Frank Hoper; Stefan Braun; Benjamin Gerlach; Hans-Dieter Brauer; Guido Schermann; Joerg G. Moser
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Paper Abstract

Chlorin type sensitizers have ideal photophysical properties for an application in PDT. The basic chlorin framework of these sensitizers has to be modified by attachment of lipophilic and hydrophilic residues to achieve a good cell uptake and tumor enrichment. In the present study we describe the selective synthesis of amphiphilic chlorins starting from the readily accessible red blood pigment heme. The photophysical properties of the well defined synthetic chlorins are characterized by photophysical investigations. The kinetic of cell uptake, the localization in the cell and the photodynamic behavior of the amphiphilic sensitizers are demonstrated by incubation of A 375 cancer cell lines with structurally different chlorins.

Paper Details

Date Published: 2 April 1996
PDF: 10 pages
Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); doi: 10.1117/12.237540
Show Author Affiliations
Franz-Peter Montforts, Univ. Bremen (Germany)
Dirk Kusch, Univ. Bremen (Germany)
Frank Hoper, Univ. Bremen (Germany)
Stefan Braun, Univ. Bremen (Germany)
Benjamin Gerlach, Univ. Bremen (Germany)
Hans-Dieter Brauer, Univ. Frankfurt (Germany)
Guido Schermann, Univ. Frankfurt (Germany)
Joerg G. Moser, Univ. Dusseldorf (Germany)


Published in SPIE Proceedings Vol. 2675:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V
Thomas J. Dougherty, Editor(s)

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