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Proceedings Paper

Influence of drug and light regimens in determining PDT efficacy with lutetium texaphyrin
Author(s): Kathryn W. Woodburn; Stuart W. Young; Richard A. Miller
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Paper Abstract

Lutetium texaphyrin (PCI-0123) is a pure, stabile, water-soluble photosensitizer with a broad absorption band centered at 732 nm. Lutetium texaphyrin has shown considerable promise in the treatment of murine mammary tumors. PDT requires the coexistence of a photosensitizer, oxygen and light. Light fluences, rates and delivery methods have a profound influence on oxygen depletion and re-equilibration and therefore tumor responsiveness. The effect of different photoirradiation and sensitizer dose in eradicating/retarding EMT6 tumors in BALB/c mice using lutetium texaphyrin was evaluated. An increase in light fluences increased efficacy. No difference was observed between a continuous versus a fractionated light protocol. A reduction in time between sensitizer injection and laser treatment enhanced tumor treatment.

Paper Details

Date Published: 2 April 1996
PDF: 7 pages
Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); doi: 10.1117/12.237535
Show Author Affiliations
Kathryn W. Woodburn, Pharmacyclics, Inc. (United States)
Stuart W. Young, Pharmacyclics, Inc. (United States)
Richard A. Miller, Pharmacyclics, Inc. (United States)


Published in SPIE Proceedings Vol. 2675:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V
Thomas J. Dougherty, Editor(s)

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