Share Email Print
cover

Proceedings Paper

Photobleaching of native and exogenous (BPD-MA) fluorescence: an in-vivo tumor-bearing rat model
Author(s): Thanassis Papaioannou; Sandor G. Vari; Vani R. Pergadia; Warren S. Grundfest; Jean-Michel I. Maarek
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

The photobleaching of the native fluorescence, as well as of the BPD-MA, an exogenous sensitizer, was measured in an in-vivo tumor bearing rat model. The photobleaching was evaluated in the time scale of seconds (approximately 0 sec - 30 sec) under continuous wave laser light irradiation at 441.6 nm. Three different sites were irradiated: the primary tumor, the mesenteric I lymph node, and the right medial iliac lymph node, at two excitation levels of 6.5 mW/mm2 (n equals 6), and approximately 35 mW/mm2 (n equals 6). Most of the fluorescence curves were adequately characterized by a biexponential decay. Increased levels of illumination were found to accelerate the photobleaching. No involvement of statistical significance of the irradiation site on the fluorescence decay was found.

Paper Details

Date Published: 2 April 1996
PDF: 9 pages
Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); doi: 10.1117/12.237531
Show Author Affiliations
Thanassis Papaioannou, Cedars-Sinai Medical Ctr. and Univ. of Southern California (United States)
Sandor G. Vari, Cedars-Sinai Medical Ctr. (United States)
Vani R. Pergadia, Cedars-Sinai Medical Ctr. (United States)
Warren S. Grundfest, Cedars-Sinai Medical Ctr. and Univ. of Southern California (United States)
Jean-Michel I. Maarek, Cedars-Sinai Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 2675:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V
Thomas J. Dougherty, Editor(s)

© SPIE. Terms of Use
Back to Top