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Proceedings Paper

Fluorescence photodiagnosis for malignant tumor
Author(s): Tetsuya Okunaka; Kinya Furukawa; Kouichi Tanaka; Hideaki Shimatani; Masahiko Harada; Hiroshi Shibuya; Shinya Okada; Jitsuo Usuda; Chimori Konaka; Katsuo Aizawa; Harubumi Kato
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Paper Abstract

The effectiveness of a new excimer laser endoscopic imaging fluorescence analyzer system using the photosensitizer, mono-L-aspartyl chlorin e6 (NPe6) for the detection of tumors was evaluated. Autofluorescence (550 plus or minus 10 nm, green fluorescence) from normal sites, red fluorescence (664 nm) of NPe6 in areas of cancer and the red fluorescence/green fluorescence ratio (R/G ratio) as the color image can be detected respectively. The greatest NPe6 fluorescence from the lesion was obtained at 3 hours after injection and the fluorescence disappeared at 24 hours. The greatest difference in the fluorescence of NPe6 and the R/G ratio in areas of tumor and in normal areas were observed at 5 hours after administration. At this period, NPe6 fluorescence from normal sites was negligible. These data suggest that fluorescence photodiagnosis may be effective in the detection of cancers.

Paper Details

Date Published: 2 April 1996
PDF: 6 pages
Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); doi: 10.1117/12.237525
Show Author Affiliations
Tetsuya Okunaka, Tokyo Medical College (Japan)
Kinya Furukawa, Tokyo Medical College (Japan)
Kouichi Tanaka, Tokyo Medical College (Japan)
Hideaki Shimatani, Tokyo Medical College (Japan)
Masahiko Harada, Tokyo Medical College (Japan)
Hiroshi Shibuya, Tokyo Medical College (Japan)
Shinya Okada, Tokyo Medical College (Japan)
Jitsuo Usuda, Tokyo Medical College (Japan)
Chimori Konaka, Tokyo Medical College (Japan)
Katsuo Aizawa, Tokyo Medical College (Japan)
Harubumi Kato, Tokyo Medical College (Japan)


Published in SPIE Proceedings Vol. 2675:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V
Thomas J. Dougherty, Editor(s)

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