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Proceedings Paper

Effect of Photofrin on skin reflection of basal cell nevus syndrome patients
Author(s): Leonard I. Grossweiner; Linda Ramball Jones; Irmgard K. Koehler; Mehmet D. Bilgin
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Paper Abstract

Skin reflection spectra were measured before and 24 hours after administration of Photofrin (Reg. TM) to basal cell nevus syndrome (BCNS) patients. The drug reduced the reflectivity of uninvolved BCNS skin and increased the reflectivity of basal cell cancers. Photofrin (Reg. TM) absorption in normal rat skin and uninvolved BCNS skin was resolved by the diffusion approximation. Optical constants calculated with a two-layer skin model indicate that the drug increased light scattering in tumor tissues. The possible use of reflection spectra for PDT light dosimetry is discussed.

Paper Details

Date Published: 2 April 1996
PDF: 11 pages
Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); doi: 10.1117/12.237521
Show Author Affiliations
Leonard I. Grossweiner, Ravenswood Hospital Medical Ctr. and Illinois Institute of Technology (United States)
Linda Ramball Jones, Medical College of Wisconsin (United States)
Irmgard K. Koehler, Ravenswood Hospital Medical Ctr. (United States)
Mehmet D. Bilgin, Illinois Institute of Technology and Ravenswood Hospital Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 2675:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V
Thomas J. Dougherty, Editor(s)

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