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Proceedings Paper

Small eye confocal scanning laser ophthalmoscopy and assessment of retinal damage
Author(s): Harry Zwick; David J. Lund; Rowe Elliot; Steven T. Schuschereba; Peter R. Edsall
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Paper Abstract

The small eye of the snake was used in combination with confocal scanning laser ophthalmoscopy to evaluate acute laser retinal damage effects at the in vivo cellular level. Because the snake eye has optical powers that allow high magnification and good ocular transmission the photoreceptors of this retina can be imaged in vivo. With a confocal scanning laser ophthalmoscope, we simultaneously imaged acute laser exposure at either the photoreceptor or epiretinal vascular layer of the snake. Equal energy 50 microjoule Argon laser exposures at 10 msecs produced larger lesion diameters and more photoreceptor loss than equal energy exposures at 80 msecs. Angiography measures demonstrated a deeper lesion depth extending for short pulse vs long pulse exposure. Q-switched 532 nm Neodymium laser exposure produced lesions more than three times the diameter of those induced with higher energy Argon laser energies. Histopathology showed selective damage to the macro and micro-oil droplet structures of this retina, suggesting an alteration in the photoreceptor optical transmission system. Pathophysiological slowing and stoppage of blood cell flow was induced following acute laser exposure.

Paper Details

Date Published: 1 April 1996
PDF: 9 pages
Proc. SPIE 2674, Laser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment, (1 April 1996); doi: 10.1117/12.237520
Show Author Affiliations
Harry Zwick, Walter Reed Army Institute of Research (United States)
David J. Lund, Walter Reed Army Institute of Research (United States)
Rowe Elliot, Walter Reed Army Institute of Research (United States)
Steven T. Schuschereba, Walter Reed Army Institute of Research (United States)
Peter R. Edsall, Walter Reed Army Institute of Research (United States)


Published in SPIE Proceedings Vol. 2674:
Laser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment
Bruce E. Stuck; Michael Belkin, Editor(s)

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