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Proceedings Paper

Molecular mechanisms of light damage to the eye and its treatment
Author(s): Joan E. Roberts; Patrick A. Bordeaux; Dan-Ning Hu; DeSales Lawless
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Paper Abstract

The eye is continually subjected to ambient radiation. The benign function of this light is to direct vision and circadian rhythm. However, under intense light from artificial sources such as lasers and operating room microscopes the natural protection of eye against light damage may be undermined. The damage can be a result of a photochemical, thermal or mechanical injury which can all disrupt ocular tissues. The mechanism for the above damage involves the production free radical and reactive oxygen intermediates either as a primary effect of the absorbance of the light or as a secondary effect due to an inflammatory response to heat or mechanical injury. This can induce a cytokine cascade as well as induce the increased production of nitric oxide. Glutathione mimics can block light induced free radical and oxygen radical intermediates in the eye. For instance, singlet oxygen is scavenged at a rate of 106 M-1 s-1; hydroxyl radical is scavenged at a rate of 109 M-1 s-1 and superoxide is scavenged at a rate of 103 M-1 s-1. In addition thiols block nitric oxide and other intermediates involved in an inflammatory response. Glutathione mimics which have offered in vivo protection against light damage to the lens and retina, have the potential to protect against laser-induced damage to the human eye.

Paper Details

Date Published: 1 April 1996
PDF: 9 pages
Proc. SPIE 2674, Laser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment, (1 April 1996); doi: 10.1117/12.237504
Show Author Affiliations
Joan E. Roberts, Fordham Univ. (United States)
Patrick A. Bordeaux, Fordham Univ. (United States)
Dan-Ning Hu, New York Eye and Ear Infirmary (United States)
DeSales Lawless, Rockefeller Univ. (United States)


Published in SPIE Proceedings Vol. 2674:
Laser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment
Bruce E. Stuck; Michael Belkin, Editor(s)

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