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Proceedings Paper

Laser-induced retinal nerve fiber layer injury in the nonhuman primate
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Paper Abstract

We have evaluated the acute effects of Argon laser injury to the retinal nerve fiber layer (NFL) in the non-human primate. Single Argon laser exposures of 150 millijoules were employed to induce retinal NFL injury. Retinal NFL injury is not acute; unlike its parallel in retinal disease it has two components that emanate from the acute retinal injury site. The ascending component is more visible, primarily because it is ascending toward the disk, representing ganglion cell axons cut off from their nutrient base, the ganglion cell body; the descending component may require up to 3 weeks to develop. Its characterization depends on the distribution of retinal NFL and the slower degeneration of the ganglion cell bodies. Fluorescein angiography suggest a retinal capillary loss that occurs in the capillary bed of the retinal NFL defect. It may reflect a reduced capillary vascular requirement of the NFL as well as a possible reduction of activity in the axonal transport mechanisms in the ascending NFL defect.

Paper Details

Date Published: 1 April 1996
PDF: 8 pages
Proc. SPIE 2674, Laser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment, (1 April 1996); doi: 10.1117/12.237497
Show Author Affiliations
Harry Zwick, Walter Reed Army Institute of Research (United States)
Michael Belkin, Walter Reed Army Institute of Research (United States)
Joseph A. Zuclich, Walter Reed Army Institute of Research (United States)
David J. Lund, Walter Reed Army Institute of Research (United States)
Steven T. Schuschereba, Walter Reed Army Institute of Research (United States)
David K. Scales, Walter Reed Army Institute of Research (United States)


Published in SPIE Proceedings Vol. 2674:
Laser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment
Bruce E. Stuck; Michael Belkin, Editor(s)

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