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Proceedings Paper

Microscopical quantification and functional simulation of pulmonary respiratory units
Author(s): Andres Kriete
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Paper Abstract

A framework for a computer-guided image acquisition procedure in confocal microscopy is described, which allows a 9-fold increase of the field of view and an extended imaging in axial direction by scanning aligned thick serial sections. Using an image compositing technique, complete respiratory units (acini) of small mammalian species (rat, mouse) could be investigated at high resolution. The quantification of the composed volume includes segmentation and topological investigation. With the help of parameters measured, a computer model of the acinus is designed to prepare functional simulations. In order to study flow of air in the acini, diffusion and the oxygen uptake, a set of mass transport equations is solved iteratively. The structural dynamics of ventilatory units during inhalation and expiration is also included.

Paper Details

Date Published: 10 April 1996
PDF: 11 pages
Proc. SPIE 2655, Three-Dimensional Microscopy: Image Acquisition and Processing III, (10 April 1996); doi: 10.1117/12.237482
Show Author Affiliations
Andres Kriete, Univ. Giessen (Germany)

Published in SPIE Proceedings Vol. 2655:
Three-Dimensional Microscopy: Image Acquisition and Processing III
Carol J. Cogswell; Gordon S. Kino; Tony Wilson, Editor(s)

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