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Proceedings Paper

Method for determining tramadol and its metabolites from urine samples
Author(s): Maria Gabriela Neicu; Radu Alexandru Macovei; Paul Şchiopu; Marian Vlădescu; Ruxandra Populeanu; Gina Caragea; Florian Grama; Alexandra Andrada Bojescu; Mihai Ionică
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Paper Abstract

Tramadol is an opioid drug used to treat moderate to moderate pain, which has two different mechanism of action. The first is due to binding to the opioid receptor, and the second is due to the inhibition of serotonin and norepinephrine reabsorption. Due to its hallucinogenic effects, tramadol is also used as a drug of abuse [1]. It is necessary to identify tramadol and its metabolites in urine specimens either for correct dosing of the tramadol in pain therapy, for monitoring the effectiveness of addiction treatment, or for acute poisoning with this opioid compound [2]. An optoelectronic gas chromatographic method coupled with mass spectrometry is presented to determine tramadol and its metabolites in urine samples [3].

Paper Details

Date Published: 31 December 2018
PDF: 4 pages
Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 109773J (31 December 2018); doi: 10.1117/12.2324762
Show Author Affiliations
Maria Gabriela Neicu, Univ. of Medicine and Pharmacy "Carol Davila" (Romania)
Radu Alexandru Macovei, Univ. of Medicine and Pharmacy "Carol Davila" (Romania)
Paul Şchiopu, Univ. Politehnica of Bucharest (Romania)
Marian Vlădescu, Univ. Politehnica of Bucharest (Romania)
Ruxandra Populeanu, Univ. of Medicine and Pharmacy "Carol Davila" (Romania)
Gina Caragea, Univ. Politehnica of Bucharest (Romania)
Medical-Military Scientific Research Ctr. (Romania)
Florian Grama, Clinical Hospital "Colţea" Bucharest (Romania)
Alexandra Andrada Bojescu, Univ. of Medicine and Pharmacy "Carol Davila" (Romania)
Medical-Military Scientific Research Ctr. (Romania)
Mihai Ionică, Univ. Politehnica of Bucharest (Romania)


Published in SPIE Proceedings Vol. 10977:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX
Marian Vladescu; Razvan D. Tamas; Ionica Cristea, Editor(s)

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