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Proceedings Paper

Optoelectronic method for determinating the selective serotonin reuptake inhibitors antidepressants
Author(s): Maria Gabriela Neicu; Radu Macovei; Paul Şchiopu; Marian Vlădescu; Ruxandra Populeanu; Gina Caragaea; Elena Truţă; Mihai Ionică
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Paper Abstract

Mass spectrometry is an optoelectronic method of identifying organic substances by comparing their mass spectrum of the analyte with the mass spectra deposited in the mass spectrum libraries of the system. High Pressure Liquid Chromatography (HPLC) coupled with Mass Spectrometry (MS) has as main objective the identification of drugs with a molecular molecule of less than 1500 amu (atomic mass units) [1]. To identify the biological products of antidepressants SSRIs have been deposited in the mass-spectra of the MI library, mass spectra obtained in a HPLC-MS interface with ElectroSpray Interface (ESI) or Atmospheric Pressure Chemical Ionization (APCI). In the paper are presented the mass spectra of selective serotonin reuptake inhibitors (SSRIs): citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline, obtained on a HPLC system MS equipped with ESI or APCI.

Paper Details

Date Published: 31 December 2018
PDF: 4 pages
Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 109773H (31 December 2018); doi: 10.1117/12.2324748
Show Author Affiliations
Maria Gabriela Neicu, Univ. of Medicine and Pharmacy "Carol Davila" (Romania)
Radu Macovei, Univ. of Medicine and Pharmacy "Carol Davila" (Romania)
Paul Şchiopu, Univ. Politehnica of Bucharest (Romania)
Marian Vlădescu, Univ. Politehnica of Bucharest (Romania)
Ruxandra Populeanu, Univ. Politehnica of Bucharest (Romania)
Gina Caragaea, Univ. Politehnica of Bucharest (Romania)
Medical-Military Scientific Research Ctr. (Romania)
Elena Truţă, Clinical Emergency Hospital Bucharest (Romania)
Mihai Ionică, Univ. Politehnica of Bucharest (Romania)
Medical-Military Scientific Research Ctr. (Romania)


Published in SPIE Proceedings Vol. 10977:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX
Marian Vladescu; Razvan D. Tamas; Ionica Cristea, Editor(s)

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