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Proceedings Paper

Optoelectronic method for the screening and confirmation of hydroxyethyl starch in urine samples
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Paper Abstract

Polysaccharide-based plasma volume expanders (PVEs) such as hydroxyethyl starch (HES) is on Prohibited List of World Anti-Doping Agency (WADA) because it can prevent dehydration and reduce haematocrit values to mask erythropoietin abuse. The aim of this study is to establish time consuming and reliable methods for doping control screening and confirmation of HES in urine samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) with the same column: 5μm Zorbax SB-C18 was used for detection and confirmation without further sample preparation. The method was validated for the parameters: specificity and matrix effect, limit of detection (250μg/mL), identification capability, carryover, robustness. The results of the both method were found to be suitable for the detection and confirmation of hydroxyethylstarch.

Paper Details

Date Published: 31 December 2018
PDF: 5 pages
Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 109773Y (31 December 2018); doi: 10.1117/12.2323819
Show Author Affiliations
Jeni-Carla Colev, Doping Control Lab. (Romania)
Bogdan Berghes, Doping Control Lab. (Romania)
Mihai Ionică, Univ. Politehnica of Bucharest (Romania)
Ctr. for Military Medical Scientific Research (Romania)

Published in SPIE Proceedings Vol. 10977:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX
Marian Vladescu; Razvan D. Tamas; Ionica Cristea, Editor(s)

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