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Proceedings Paper

Multiple reactions monitoring for determinating methadone and its metabolite
Author(s): Ruxandra Populeanu; Radu Alexandru Macovei; Marian Vlădescu; Genica Caragea; Ruxandra Avram; Mihai Ionică
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Paper Abstract

Methadone is an opioid used in medicine as an analgesic and antidependent maintenance in opioid dependent patients. It is used in the substitution treatment for heroin or other opiates. Methadone belongs to the category of special drugs with a very high potential for dependence and a low lethal dose [1]. Mass spectrometry is an optoelectronic method for determining organic substances by comparing their mass spectrum with mass spectra found in the NIST, Wiley, PMW, and other mass spectrum libraries. In the case of biological products, substances of interest, biotic or xenobiotics may be "hidden" from the noise of the analyzed matrix. A method was developed on a gas chromatograph coupled with a Varian Mass Spectrometer (GC-MS) [2, 3]. The authors presented two methods of increasing sensitivity and signal / noise ratio for the identification of methadone and its metabolites by dissociating ion-specific parent ion for methadone and its metabolites to obtain an MS/MS spectrum.

Paper Details

Date Published: 31 December 2018
PDF: 4 pages
Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 109773A (31 December 2018); doi: 10.1117/12.2323612
Show Author Affiliations
Ruxandra Populeanu, Univ. Politehnica of Bucharest (Romania)
Radu Alexandru Macovei, Clinical Emergency Hospital Bucharest (Romania)
Marian Vlădescu, Univ. Politehnica of Bucharest (Romania)
Genica Caragea, Clinical Emergency Hospital Bucharest (Romania)
Military-Medical Scientific Research Ctr. (Romania)
Ruxandra Avram, Clinical Emergency Hospital Bucharest (Romania)
Military-Medical Scientific Research Ctr. (Romania)
Mihai Ionică, Univ. Politehnica of Bucharest (Romania)
Military-Medical Scientific Research Ctr. (Romania)


Published in SPIE Proceedings Vol. 10977:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX
Marian Vladescu; Razvan D. Tamas; Ionica Cristea, Editor(s)

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