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Proceedings Paper

Multiple reactions monitoring for cocaine and ethylbenzoylecgonine to increase the signal/noise ratio in mass spectrometry analysis
Author(s): Ruxandra Populeanu; Radu Alexandru Macovei; Marian Vlădescu; Gabriela Anghelescu; Genica Caragea; Alexandra Andrada Bojescu; Mihai Ionică
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Paper Abstract

Drug abuse consists of the use by a subject without a medical recommendation, in quantities or with nonrecommended methods. Substance abuse also refers to their use in order to increase intellectual or physical performance, against the rules established by society. Substance abuse involves the chronic use of non-medical chemicals for hedonistic or entheogenic purposes [1]. Drugs such as alcohol, antidepressants, amphetamine, barbiturates, benzodiazepines, cannabinoids, glue, cocaine, hallucinogens, metacular, narcotics, opiates, sedatives, stimulants and some organic solvents can be named [2]. Substance abuse can cause criminal or antisocial behavior, may generate long-term changes in personality [3].

Cocaine has major toxic effects on the body. Treatment of cocaine poisoning is complex. The main sales are those that can lead to patient death. For the proper treatment of any inoculation, it is necessary to identify the xenobiotic that generated it. The presence of metabolites, in the case of cocaine - ethylbenzoylcogene (EBE), provides information on the time of administration of the xenobiotic.

Gas chromatography or liquid chromatography coupled with mass spectrometry is an optoelectronic method that can identify the presence of cocaine and / or EBE from biological samples. In order to increase the sensitivity of the method, a special mass metrology technique - MS/MS can be used [4, 5].

Paper Details

Date Published: 31 December 2018
PDF: 4 pages
Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 1097738 (31 December 2018); doi: 10.1117/12.2322569
Show Author Affiliations
Ruxandra Populeanu, Univ. Politehnica of Bucharest (Romania)
Radu Alexandru Macovei, Clinical Emergency Hospital Bucharest (Romania)
Univ. of Medicine and Pharmacy "Carol Davila" (Romania)
Marian Vlădescu, Univ. Politehnica of Bucharest (Romania)
Gabriela Anghelescu, Clinical Hospital Târgovişte (Romania)
Genica Caragea, Clinical Emergency Hospital Bucharest (Romania)
Military-Medical Scientific Research Ctr. (Romania)
Alexandra Andrada Bojescu, Univ. of Medicine and Pharmacy "Carol Davila" (Romania)
Mihai Ionică, Univ. Politehnica of Bucharest (Romania)
Military-Medical Scientific Research Ctr. (Romania)

Published in SPIE Proceedings Vol. 10977:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX
Marian Vladescu; Razvan D. Tamas; Ionica Cristea, Editor(s)

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