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Proceedings Paper

Rapid sensing of iodine ions on stress-activated pyrolytic carbon nanostructures (Conference Presentation)
Author(s): Olivia R. Benice; EunByul Cho; Sunshine Holmberg; Maziar Ghazinejad; Marc J. Madou
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Paper Abstract

Iodine is an essential micronutrient in modulating critical functions of the body, such as producing thyroid hormones. A deficiency of iodine can cause severe thyroid-related disorders [2], while high doses of iodine can trigger overproduction of thyroid hormones, increasing the risk of developing thyroid dysfunction [1,2]. Therefore, it is critical to assess the iodine concentration in body fluids to monitor and diagnose early signs of diseases. Here we report on a simple, rapid, and highly-sensitive electrochemical detection of urinary iodine (UI) by exploiting the exceptional electrocatalytic capabilities of stress-activated pyrolytic carbon nanofibers (SAPCs). SAPCs are synthesized by stress-induced molecular alignment and subsequent low-temperature pyrolysis of organic carbon precursors. The resulting carbon possesses highly-graphitic structures that are characteristically rich in nitrogen heteroatoms and edge planes [3,4]. The tunable surface of SAPCs can also enhance the sensitivity and specificity of iodide ions in human urine. Furthermore, the high macroporosity of SAPCs increases surface area, creating a large liquid-carbon junction in aqueous solutions, providing efficient ion transport and adsorption capacity. The sensitivity and limit of detection (LoD) of SAPCs were evaluated by obtaining the linearity of molar concentration of iodide ions (I-) vs. current. The sensor specificity of SAPCs electrode for iodide ions was also investigated by adding a series of competitive anions such as F-, Cl-, PO43-, HPO42-, and H2PO4- into the solution and evaluating the effect of interference substances electrochemically. Additionally, the reproducibility of SAPCs for iodide ion detection was assessed by measuring the inter- and intra- coefficients of variability (CV%).

Paper Details

Date Published: 17 September 2018
Proc. SPIE 10728, Biosensing and Nanomedicine XI, 1072809 (17 September 2018); doi: 10.1117/12.2320908
Show Author Affiliations
Olivia R. Benice, Univ. of California, Irvine (United States)
EunByul Cho, Univ of California, Irvine (United States)
Sunshine Holmberg, Univ. of California, Irvine (United States)
Maziar Ghazinejad, California State Univ., Fresno (United States)
Marc J. Madou, Univ. of California, Irvine (United States)

Published in SPIE Proceedings Vol. 10728:
Biosensing and Nanomedicine XI
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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