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Clinical applications of the Mueller-matrix reconstruction of the polycrystalline structure of multiple-scattering biological tissues
Author(s): Yu. A. Ushenko; A. V. Dubolazov; O. V. Olar; S. O. Sokolnyk; G. B. Bodnar; L. Pidkamin; O. Prydiy; M. I. Sidor
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Paper Abstract

A multilayered model of the optical anisotropy of the light-scattering layer of biological tissue is considered. The Muller matrix of the depolarizing layer is represented as a superposition of partial matrix operators for linear and circular birefringence-dichroism. For multiple scattering, an algorithm is proposed for the expansion of the Muller matrix in the form of two components. The first is the fully polarized component of the Muller matrix. The second is the completely depolarized component of the Muller matrix. The algorithms for measuring the elements of the fully polarized component of the Muller matrix for distributions of the phase and amplitude anisotropy of the depolarizing biological tissue are found. Maps of the distributions of the completely polarized component of the Muller matrix elements of histological sections of healthy and diabetic rats liver tissue have been studied. Sensitivity, specificity and balanced accuracy of the Muller-matrix reconstruction method of the polycrystalline structure of multiply scattering biological tissues are determined. Within the framework of the statistical analysis of the maps of the elements of the fully polarized component of the Muller matrix, histological sections of the liver tissue, objective criteria for the differentiation of healthy and diabetic rats have been found.

Paper Details

Date Published: 5 September 2018
PDF: 8 pages
Proc. SPIE 10728, Biosensing and Nanomedicine XI, 107280P (5 September 2018); doi: 10.1117/12.2320527
Show Author Affiliations
Yu. A. Ushenko, Yuriy Fedkovych Chernivtsi National Univ. (Ukraine)
A. V. Dubolazov, Yuriy Fedkovych Chernivtsi National Univ. (Ukraine)
O. V. Olar, Yuriy Fedkovych Chernivtsi National Univ. (Ukraine)
S. O. Sokolnyk, Bukovinian State Medical Univ. (Ukraine)
G. B. Bodnar, Bukovinian State Medical Univ. (Ukraine)
L. Pidkamin, Yuriy Fedkovych Chernivtsi National Univ. (Ukraine)
O. Prydiy, Yuriy Fedkovych Chernivtsi National Univ. (Ukraine)
M. I. Sidor, Yuriy Fedkovych Chernivtsi National Univ. (Ukraine)


Published in SPIE Proceedings Vol. 10728:
Biosensing and Nanomedicine XI
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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