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Proceedings Paper

Enhanced therapeutic effect of an antitumor agent on malignant glioma in rats by photomechanical wave-based transvascular drug delivery
Author(s): Yumiko Koshi; Yasuyuki Tsunoi; Arata Tomiyama; Satoko Kawauchi; Kentaro Mori; Shunichi Sato; Izumi Nishidate
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Paper Abstract

Malignant glioma is one of the most deadly malignancies due to the blood-brain barrier (BBB), which limits the delivery of an antitumor drug to the tumor. In this study, we used a nanosecond pulsed laser-induced photomechanical wave (PMW) to enhance the delivery efficiency of an antitumor drug, temozolomide (TMZ) through the blood-brain barrier (BBB) in a F98 rat glioma model. Seven days after glioma cell injection into the brain, rats were divided into four groups: control without any treatment (group 1); PMW application alone (group 2); TMZ application alone (group 3); and combined application of PMW and TMZ (group 4). Seven days after these treatments, rats were sacrificed and tumor sizes were evaluated. The tumor size of group 4 was significantly smaller than that of group 1, while there was no significant difference in the tumor size between group1 and group 3. This shows that the therapeutic effect of TMZ can be enhanced by PMW application.

Paper Details

Date Published: 24 April 2018
PDF: 3 pages
Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 1071111 (24 April 2018); doi: 10.1117/12.2319269
Show Author Affiliations
Yumiko Koshi, Tokyo Univ. of Agriculture and Technology (Japan)
Yasuyuki Tsunoi, National Defense Medical College Research Institute (Japan)
Arata Tomiyama, National Defense Medical College (Japan)
Satoko Kawauchi, National Defense Medical College Research Institute (Japan)
Kentaro Mori, National Defense Medical College (Japan)
Shunichi Sato, National Defense Medical College Research Institute (Japan)
Izumi Nishidate, Tokyo Univ. of Agriculture and Technology (Japan)


Published in SPIE Proceedings Vol. 10711:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji; Yuan Luo, Editor(s)

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