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Mammographic breast density over time among women who have participated in BreastScreen Norway
Author(s): Nataliia Moshina; Gunvor G. Wåde; Marta Roman; Sofie Sebuødegård; Solveig Hofvind
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Paper Abstract

Background

We analyzed the consistency in absolute and percent density using an automated method for estimating volumetric breast density among women who attended BreastScreen Norway 2007-2015.

Material and Methods

We used information from 33,711 women aged 50-69 who underwent two to five full field digital screening examinations biennially, 2007-2015. BMI and HT-use was obtained from a self-administered questionnaire, sent together with the invitation to screening. BMI was categorized into <21.0; 21.0-24.9; ≥25.0 kg/m2, while use of HT was defined as ever versus never used. An automated method estimated fibroglandular volume (cm3), breast volume (cm3) and volumetric breast density (%) for each screening examination. We applied mixed-effects linear models to estimate associations between age, fibroglandular volume, breast volume and volumetric breast density over time including data on BMI and HT.

Results

The results models indicated age to be associated with decreased fibroglandular volume and volumetric breast density, and increased breast volume. BMI <21 kg/m2 was associated with higher volumetric breast density, but lower fibroglandular and breast volume. Contrary, BMI ≥25 kg/m2 was associated with lower volumetric breast density and higher fibroglandular and breast volumes. Variation in volumetric breast density and fibroglandular volume within women was rather subtle: this variance did not exceed 10% for either volumetric breast density, fibroglandular volume or breast volume.

Conclusion

Automated measures of volumetric breast density and fibroglandular volume software decreased with age among women screened in BreastScreen Norway. Absolute and percent density varied with a maximum of 10% over time, from first to last screening examination.

Paper Details

Date Published: 6 July 2018
PDF: 7 pages
Proc. SPIE 10718, 14th International Workshop on Breast Imaging (IWBI 2018), 107180C (6 July 2018); doi: 10.1117/12.2317927
Show Author Affiliations
Nataliia Moshina, The Cancer Registry of Norway (Norway)
Gunvor G. Wåde, Oslo Metropolitan Univ. (Norway)
Marta Roman, Hospital del Mar Medical Research Institute (Spain)
Research Network on Health Services in Chronic Diseases (Spain)
Sofie Sebuødegård, The Cancer Registry of Norway (Norway)
Solveig Hofvind, The Cancer Registry of Norway (Norway)
Oslo Metropolitan Univ. (Norway)


Published in SPIE Proceedings Vol. 10718:
14th International Workshop on Breast Imaging (IWBI 2018)
Elizabeth A. Krupinski, Editor(s)

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