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Proceedings Paper

Identification of breast tissue using the x-ray image measured with an energy-resolved cadmium telluride series detector based on photon-counting technique
Author(s): Mariko Sasaki; Shuji Koyama; Yoshie Kodera; Reina Suzuki; Ai Nakajima; Hiroko Nishide; Mitsuhiro Mizutani; Megumi Watanabe; Naoko Yoshida; Hiroaki Hayashi; Tsutomu Yamakawa; Shuichiro Yamamoto; Daisuke Hashimoto; Masahiro Okada
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Paper Abstract

We have been developing a new mammography device with a cadmium-telluride series energy-resolved photon-counting X-ray detector. Using a photon-counting technique, we examined the sensitivity of the system for differentiating the composition of breast tissue and detecting breast tumors. To differentiate breast tissues, we prepared surgically resected specimens fixed in formalin, consisting of adipose, mammary-gland, and tumor tissues. In order to obtain the values of certain effective atomic numbers, we prepared phantoms with 0%, 50% and 100% simulated mammary-gland tissue. In our imaging system, the X-ray spectrum penetrating the object was measured using three energy bins, and the products of linear attenuation coefficients and thicknesses for the three bins were calculated. These linear attenuation coefficients were properly corrected for beam hardening and normalized, to ignore the thickness. These calculations were applied for each pixel, and the gravity point per ROI (region of interest) was plotted on scatterplots to examine their distribution. Adiposetissue values were similar to known values; however, mammary-gland values were distant from expected values. In most specimens, the tumor points were focused; however, in some specimens, it was difficult to distinguish between tumor and mammary-gland tissues given their close linear attenuation coefficients. Mammary-gland tissues may have been influenced by formalin, given its tubular structure.

Paper Details

Date Published: 6 July 2018
PDF: 6 pages
Proc. SPIE 10718, 14th International Workshop on Breast Imaging (IWBI 2018), 107181Z (6 July 2018); doi: 10.1117/12.2317819
Show Author Affiliations
Mariko Sasaki, Nagoya Univ. Graduate School of Medicine (Japan)
Shuji Koyama, Nagoya Univ. Graduate School of Medicine (Japan)
Yoshie Kodera, Nagoya Univ. Graduate School of Medicine (Japan)
Reina Suzuki, Nagoya Univ. Graduate School of Medicine (Japan)
Ai Nakajima, Nagoya Univ. Graduate School of Medicine (Japan)
Hiroko Nishide, Gifu Univ. of Medical Science (Japan)
Mitsuhiro Mizutani, Mikawa Breast Cancer Clinic (Japan)
Megumi Watanabe, Mikawa Breast Cancer Clinic (Japan)
Naoko Yoshida, Mikawa Breast Cancer Clinic (Japan)
Hiroaki Hayashi, Kanazawa Univ. (Japan)
Tsutomu Yamakawa, JOB Corp. (Japan)
Independent Consultant (Japan)
Shuichiro Yamamoto, JOB Corp. (Japan)
Daisuke Hashimoto, JOB Corp. (Japan)
Masahiro Okada, JOB Corp. (Japan)


Published in SPIE Proceedings Vol. 10718:
14th International Workshop on Breast Imaging (IWBI 2018)
Elizabeth A. Krupinski, Editor(s)

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