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Proceedings Paper

Characterization of cancer metastasis in model mice by multiphoton microscopy and Raman spectroscopy
Author(s): Yusuke Oshima; Shigehiro Koga; Hiromi Yamamoto; Yuji Watanabe
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Paper Abstract

Raman spectroscopy provides a wealth of diagnostic information to the surgeon with in situ cancer detection and labelfree histopathology in clinical practice. However, to identify cancer diagnostic biomarkers in vivo is still challenging, because malignancy can be characterized not only by the cancer cells but also by the environmental factors. Here we investigate molecular dynamics in both cancer cells and their environment in xenograft models and spontaneous metastasis models using Raman spectroscopy and nonlinear optical imaging. We are constructing a custom-designed Raman spectral imaging system to reveal the metastasis process and to evaluate therapeutics toward the clinical application of the technique.

Paper Details

Date Published: 24 April 2018
PDF: 2 pages
Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 107110X (24 April 2018); doi: 10.1117/12.2317041
Show Author Affiliations
Yusuke Oshima, Tohoku Univ. (Japan)
Ehime Univ. Hospital (Japan)
Ehime Univ. Graduate School of Medicine (Japan)
Shigehiro Koga, Ehime Univ. Graduate School of Medicine (Japan)
Hiromi Yamamoto, Ehime Univ. Hospital (Japan)
Yuji Watanabe, Ehime Univ. Graduate School of Medicine (Japan)


Published in SPIE Proceedings Vol. 10711:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji; Yuan Luo, Editor(s)

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