Share Email Print
cover

Proceedings Paper

Tissue diagnostics by depth profiling of optical characteristics using broadband fiber optic interferometry
Author(s): Robert Splinter; Faramarz Farahi; M. Yasin Akhtar Raja; Robert H. Svenson
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

A broadband interferometer is used to acquire scattered light as a function of depth in biological media. The `tissue-light-signature' that is obtained by this depth scan can be correlated with the computer simulated light distributions for well defined tissue parameters, and wavelengths of specific interest. In theory, the collimated irradiation of heart tissue, by low coherence light will generate a statistically significant different light signature for respective myocardial tissues, and pathological tissue conditions. Interferometric axial scanning of in vitro myocardial tissues confirmed the statistically significant difference between normal, coagulated myocardium, and aneurysm at the 790 nm wavelength. The scanning depth however is presented limited by the intensity of the illumination and the choice of detection scheme. Identification of the local optical characteristics as a function of depth directly underneath the target zone will provide discrimination between healthy and pathological conditions in addition to real time assessment of laser dosimetry. Theoretically the scanning depth is limited to a maximum of 4 mm. The beam profile of the irradiation source significantly affects the ability to distinguish between certain tissues. Broadband interferometric axial tissue scanning, will provide a tool for an accurate light energy delivery guided by the desired outcome, while being able to verify the appropriate target location, in real time.

Paper Details

Date Published: 9 February 1996
PDF: 9 pages
Proc. SPIE 2732, CIS Selected Papers: Coherence-Domain Methods in Biomedical Optics, (9 February 1996); doi: 10.1117/12.231680
Show Author Affiliations
Robert Splinter, Carolinas Medical Ctr., Univ. of North Carolina/Charlotte (United States)
Faramarz Farahi, Univ. of North Carolina/Charlotte (United States)
M. Yasin Akhtar Raja, Univ. of North Carolina/Charlotte (United States)
Robert H. Svenson, Carolinas Medical Ctr., Univ. of North Carolina/Charlotte (United States)


Published in SPIE Proceedings Vol. 2732:
CIS Selected Papers: Coherence-Domain Methods in Biomedical Optics
Valery V. Tuchin, Editor(s)

© SPIE. Terms of Use
Back to Top