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Proceedings Paper

Confocal scanning laser ophthalmoscopic imaging resolution of secondary retinal effects induced by laser radiation
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Paper Abstract

We have evaluated secondary laser induced retinal effects in non-human primates with a Rodenstock confocal scanning laser ophthalmoscope. A small eye animal model, the Garter snake, was employed to evaluate confocal numerical aperture effects in imaging laser retinal damage in small eyes vs. large eyes. Results demonstrate that the confocal image resolution in the Rhesus monkey eye is sufficient to differentiate deep retinal scar formation from retinal nerve fiber layer (NFL) damage and to estimate the depth of the NFL damage. The best comparison with histological depth was obtained for the snake retina, yielding a ratio close to 1:1 compared to 2:1 for the Rhesus. Resolution in the Garter snake allows imaging the photoreceptor matrix and therefore, evaluation of the interrelationship between the primary damage site (posterior retina), the photoreceptor matrix, and secondary sites in the anterior retina such as the NFL and the epiretinal vascular system. Alterations in both the retinal NFL and epiretinal blood flow rate were observed within several minutes post Argon laser exposure. Unique aspects of the snake eye such as high tissue transparency and inherently high contrast cellular structures, contribute to the confocal image quality. Such factors may be nearly comparable in primate eyes suggesting that depth of resolution can be improved by smaller confocal apertures and more sensitive signal processing techniques.

Paper Details

Date Published: 9 February 1996
PDF: 12 pages
Proc. SPIE 2732, CIS Selected Papers: Coherence-Domain Methods in Biomedical Optics, (9 February 1996); doi: 10.1117/12.231676
Show Author Affiliations
Harry Zwick, Walter Reed Army Institute of Research (United States)
David J. Lund, Walter Reed Army Institute of Research (United States)
Bruce E. Stuck, Walter Reed Army Institute of Research (United States)
Joseph A. Zuclich, Walter Reed Army Institute of Research (United States)
Rowe Elliot, Univ. of Texas Health Science Ctr. (United States)
Steven T. Schuschereba, Walter Reed Army Institute of Research (United States)
Donald A. Gagliano, Walter Reed Army Institute of Research (United States)
M. Belkin, Walter Reed Army Institute of Research (United States)
Randolph D. Glickman, Univ. of Texas Health Science Ctr. (United States)


Published in SPIE Proceedings Vol. 2732:
CIS Selected Papers: Coherence-Domain Methods in Biomedical Optics
Valery V. Tuchin, Editor(s)

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