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In vivo time-series monitoring of dermal collagen fiber during skin burn healing using second-harmonic-generation microscopy
Author(s): Eiji Hase; Ryosuke Tanaka; Shu-ichiro Fukushima; Takeshi Yasui
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Paper Abstract

Burn healing is a process to repair thermally damaged tissues. Although burn healing has many aspects, it is common for dynamics of collagen fiber to be closely related with burn healing. If such healing process can be visualized from the viewpoint of the collagen dynamics, one may obtain new findings regarding biological repairing mechanisms in the healing process. In this paper, we applied second-harmonic-generation microscopy for in vivo imaging of the healing process in animal skin burn and successfully visualized the decomposition, production, and growth of renewal collagen fibers as a series of time-lapse images in the same subject.

Paper Details

Date Published: 24 April 2018
PDF: 5 pages
Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 107111B (24 April 2018); doi: 10.1117/12.2316748
Show Author Affiliations
Eiji Hase, Tokushima Univ. (Japan)
JASRI/SPring-8 (Japan)
Ryosuke Tanaka, Osaka Univ. (Japan)
Shu-ichiro Fukushima, Osaka Univ. (Japan)
Takeshi Yasui, Tokushima Univ. (Japan)
Osaka Univ. (Japan)


Published in SPIE Proceedings Vol. 10711:
Biomedical Imaging and Sensing Conference
Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji; Yuan Luo, Editor(s)

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