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Proceedings Paper

In vitro terahertz spectroscopy of gelatin-embedded human brain tumors: a pilot study
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Paper Abstract

We have performed the in vitro terahertz (THz) spectroscopy of human brain tumors. In order to fix tissues for the THz measurements, we have applied the gelatin embedding. It allows for preserving tissues from hydration/dehydration and sustaining their THz response similar to that of the freshly-excised tissues for a long time after resection. We have assembled an experimental setup for the reflection-mode measurements of human brain tissues based on the THz pulsed spectrometer. We have used this setup to study in vitro the refractive index and the amplitude absorption coefficient of 2 samples of malignant glioma (grade IV), 1 sample of meningioma (grade I), and samples of intact tissues. We have observed significant differences between the THz responses of normal and pathological tissues of the brain. The results of this paper highlight the potential of the THz technology in the intraoperative neurodiagnosis of tumors relying on the endogenous labels of tumorous tissues.

Paper Details

Date Published: 26 April 2018
PDF: 9 pages
Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107160S (26 April 2018); doi: 10.1117/12.2316302
Show Author Affiliations
N. V. Chernomyrdin, Bauman Moscow State Technical Univ. (Russian Federation)
Prokhorov General Physics Institute (Russian Federation)
Sechenov First Moscow State Medical Univ. (Russian Federation)
A. A. Gavdush, Bauman Moscow State Technical Univ. (Russian Federation)
S.-I. T. Beshplav, Burdenko Neurosurgery Institute (Russian Federation)
K. M. Malakhov, Bauman Moscow State Technical Univ. (Russian Federation)
A. S. Kucheryavenko, Bauman Moscow State Technical Univ. (Russian Federation)
G. M. Katyba, Institute of Solid State Physics (Russian Federation)
I. N. Dolganova, Bauman Moscow State Technical Univ. (Russian Federation)
S. A. Goryaynov, Burdenko Neurosurgery Institute (Russian Federation)
V. E. Karasik, Bauman Moscow State Technical Univ. (Russian Federation)
I. E. Spektor, Prokhorov General Physics Institute (Russian Federation)
V. N. Kurlov, Institute of Solid State Physics (Russian Federation)
S. O. Yurchenko, Bauman Moscow State Technical Univ. (Russian Federation)
G. A. Komandin, Prokhorov General Physics Institute (Russian Federation)
A. A. Potapov, Burdenko Neurosurgery Institute (Russian Federation)
V. V. Tuchin, Saratov State Univ. (Russian Federation)
Institute of Precision Mechanics and Control (Russian Federation)
Tomsk State Univ. (Russian Federation)
K. I. Zaytsev, Bauman Moscow State Technical Univ. (Russian Federation)
A.M. Prokhorov General Physics Institute (Russian Federation)
Sechenov First Moscow State Medical Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 10716:
Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX
Valery V. Tuchin; Elina A. Genina; Vladimir L. Derbov; Dmitry Engelevich Postnov, Editor(s)

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