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Proceedings Paper

Noninvasive control of rhodamine-loaded capsules distribution in vivo
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Paper Abstract

Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.

Paper Details

Date Published: 26 April 2018
PDF: 6 pages
Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 1071619 (26 April 2018); doi: 10.1117/12.2315773
Show Author Affiliations
O. Stelmashchuk, Orel State Univ. (Russian Federation)
Y. Tarakanchikova , Univ. of Oulu (Finland)
Saratov State Univ. (Russian Federation)
First I.P. Pavlov State Medical Univ. of St. Petersburg (Russian Federation)
E. Seryogina, Orel State Univ. (Russian Federation)
G. Piavchenko, Orel State Univ. (Russian Federation)
Ctr. of Preclinical Research, CJSC "Retinoids" (Russian Federation)
E. Zherebtsov, Aston Univ. (United Kingdom)
A. Dunaev, Orel State Univ. (Russian Federation)
A. Popov, Orel State Univ. (Russian Federation)
ITMO Univ. (Russian Federation)
I. Meglinski, Univ. of Oulu (Finland)
Orel State Univ. (Russian Federation)
ITMO Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 10716:
Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX
Valery V. Tuchin; Elina A. Genina; Vladimir L. Derbov; Dmitry Engelevich Postnov, Editor(s)

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