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Diatomite nanovectors uptake in cancer cells: a Raman imaging study
Author(s): S. Managò; N. Migliaccio; M. Terracciano; M. Napolitano; N. M. Martucci; L. De Stefano; I. Rendina; A. Lamberti; I. Rea; A. C. De Luca
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Paper Abstract

In this work, we employed the Raman microscopy to study the internalization kinetics and spatial distribution of small interfering RNA (siRNA)-diatomite nanoparticles (DNPs) complex in human lung epidermoid carcinoma cell line (H1355) up to 72 h. Raman images are compared with confocal fluorescence microscopy results. The Raman analysis provides that the siRNA-DNPs are internalized and co-localized in lipid vesicles within 18 h, after that equilibrium is achieved.

Paper Details

Date Published: 17 May 2018
PDF: 7 pages
Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106854J (17 May 2018); doi: 10.1117/12.2315371
Show Author Affiliations
S. Managò, National Research Council (Italy)
N. Migliaccio, Univ. degli Studi di Napoli Federico II (Italy)
M. Terracciano, Institute for Microelectronics and Microsystems, National Research Council (Italy)
M. Napolitano, National Research Council (Italy)
N. M. Martucci, Univ. degli Studi di Napoli Federico II (Italy)
L. De Stefano, Institute for Microelectronics and Microsystems, National Research Council (Italy)
I. Rendina, Institute for Microelectronics and Microsystems, National Research Council (Italy)
A. Lamberti, Univ. degli Studi di Napoli Federico II (Italy)
I. Rea, Institute for Microelectronics and Microsystems, National Research Council (Italy)
A. C. De Luca, National Research Council (Italy)


Published in SPIE Proceedings Vol. 10685:
Biophotonics: Photonic Solutions for Better Health Care VI
Jürgen Popp; Valery V. Tuchin; Francesco Saverio Pavone, Editor(s)

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