Share Email Print
cover

Proceedings Paper

The lymphatic mechanisms of brain cleaning: application of optical coherence tomography and fluorescence microscopy
Author(s): O. Glushkovskaya-Semyachkina; A. Abdurashitov; I. Fedosov; A. Namykin; A. Pavlov; A. Shirokov; N. Shushunova; O. Sindeeva; A. Khorovodov; M. Ulanova; V. Sagatova; I. Agranovich; A. Bodrova; J. Kurths
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Here we studied the role of cerebral lymphatic system in the brain clearing using intraparenchymal injection of Evans Blue and gold nanorods assessed by optical coherent tomography and fluorescence microscopy. Our data clearly show that the cerebral lymphatic system plays an important role in the brain cleaning via meningeal lymphatic vessels but not cerebral veins. Meningeal lymphatic vessels transport fluid from the brain into the deep cervical node, which is the first anatomical “station” for lymph outflow from the brain. The lymphatic processes underlying brain clearing are more slowly vs. peripheral lymphatics. These results shed light on the lymphatic mechanisms responsible for brain clearing as well as interaction between the intra- and extracranial lymphatic compartment.

Paper Details

Date Published: 26 April 2018
PDF: 6 pages
Proc. SPIE 10717, Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV, 107171V (26 April 2018); doi: 10.1117/12.2315199
Show Author Affiliations
O. Glushkovskaya-Semyachkina, Saratov State Univ. (Russian Federation)
A. Abdurashitov, Saratov State Univ. (Russian Federation)
I. Fedosov, Saratov State Univ. (Russian Federation)
A. Namykin, Saratov State Univ. (Russian Federation)
A. Pavlov, Yuri Gagarin State Technical Univ. of Saratov (Russian Federation)
A. Shirokov, Institute of Bioorganic Chemistry (Russian Federation)
N. Shushunova, Saratov State Univ. (Russian Federation)
O. Sindeeva, Saratov State Univ. (Russian Federation)
A. Khorovodov, Saratov State Univ. (Russian Federation)
M. Ulanova, Saratov State Univ. (Russian Federation)
V. Sagatova, Saratov State Univ. (Russian Federation)
I. Agranovich, Saratov State Univ. (Russian Federation)
A. Bodrova, Saratov State Univ. (Russian Federation)
J. Kurths, Saratov State Univ. (Russian Federation)
Potsdam Institute for Climate Impact Research (Germany)
Humboldt Univ. Berlin (Germany)


Published in SPIE Proceedings Vol. 10717:
Saratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV
Vladimir L. Derbov; Dmitry Engelevich Postnov, Editor(s)

© SPIE. Terms of Use
Back to Top