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Structural features of blood lymphocytes according to data of atomic force microscopy in alloxan induced diabetic rats
Author(s): Olga V. Stolbovskaya; Radik M. Khayrullin; Boris B. Kostishko; Rinat I. Bakhtiyarov
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Paper Abstract

Structural changes in blood lymphocytes during the development of alloxan induced diabetes in rats were revealed. The changes were characterized by decreased volume, surface area, flatness coefficient of cells in comparison with normal lymphocytes. A consistent increase in the Young's modulus of rat lymphocytes during the development of diabetes in comparison with the Young's modulus of normal lymphocytes has been established, which indicates a decrease of the elastic-viscous properties of the cell membrane, changes in the molecular structure of its and in the organization of the lymphocyte cytoskeleton. It was found that during the development of induced diabetes the roughness and adhesiveness of the cytoplasmic membrane of blood lymphocytes decrease.

Paper Details

Date Published: 26 April 2018
PDF: 6 pages
Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107160F (26 April 2018); doi: 10.1117/12.2315077
Show Author Affiliations
Olga V. Stolbovskaya, Ulyanovsk State Univ. (Russian Federation)
Radik M. Khayrullin, Ulyanovsk State Univ. (Russian Federation)
Boris B. Kostishko, Ulyanovsk State Univ. (Russian Federation)
Rinat I. Bakhtiyarov, Ulyanovsk State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 10716:
Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX
Valery V. Tuchin; Elina A. Genina; Vladimir L. Derbov; Dmitry Engelevich Postnov, Editor(s)

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