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Proceedings Paper

Multimodal fluorescence imaging navigation for surgical guidance of malignant tumors in photosensitized tissues of neural system and other organs
Author(s): Maxim Loshchenov; Walter Blondel ; Marine Amouroux ; Rudolf Steiner ; Aleksandr Potapov ; Denis Golbin; Oleg Loran; Akobirkhon Babaev ; Aleksandr Borodkin; Christian Daul; Dinh-Hoan Trinh; Victor Loschenov
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Paper Abstract

A 5-ALA-induced fluorescence-based imaging device for guidance during surgery of malignant and non-malignant preliminary photosensitized tumors is presented. The setup fits existing clinical optical rigid and flexible endoscopes and operation microscopes. It consists of three light sources including white light, red light fluorescence excitation and blue light fluorescence excitation sources. The light from any combination of the latter sources is delivered to tissue using specially designed fiber optic light guide. Two cameras are used to acquire fluorescence and back reflected white light images: a gray-level camera for fluorescence in the far red range and a color camera for white light images. A dichroic mirror is implemented to spectrally split the light coming from tissue. Images from both cameras are processed into a computer with specially developed software where it can be displayed in different modes including overlaying or been used for image mosaicing which allows for increasing the intrinsic reduced field of view of endoscopes by providing highly resolved extended cartography. Experiments were carried out on phantoms and on patients in clinical conditions during surgery of brain and other tissues. Blue light excitation was more sensitive for thin tumors but red light excitation was more beneficial for solid tumors and for navigation in presence of slight bleeding.

Paper Details

Date Published: 24 May 2018
PDF: 10 pages
Proc. SPIE 10677, Unconventional Optical Imaging, 106773N (24 May 2018); doi: 10.1117/12.2311273
Show Author Affiliations
Maxim Loshchenov, A. M. Prokhorov General Physics Institute of the Russian Academy of Sciences (Russian Federation)
Walter Blondel , Univ. de Lorraine, CNRS, Ctr. National de la Recherche Scientifique (France)
Marine Amouroux , Univ. de Lorraine, CNRS, Ctr. National de la Recherche Scientifique (France)
Rudolf Steiner , Univ. of Ulm (Germany)
Aleksandr Potapov , N .N. Burdenko National Scientific and Practical Ctr. for Neurosurgery (Russian Federation)
Denis Golbin, N .N. Burdenko National Scientific and Practical Ctr. for Neurosurgery (Russian Federation)
Oleg Loran, Department of "Urology and Surgical Andrology" of the Russian Academy of Postgraduate Education (Russian Federation)
Akobirkhon Babaev , Department of "Urology and Surgical Andrology" of the Russian Academy of Postgraduate Education (Russian Federation)
Aleksandr Borodkin, A. M. Prokhorov General Physics Institute of the Russian Academy of Sciences (Russian Federation)
Christian Daul, Univ. de Lorraine, CNRS, Ctr. National de la Recherche Scientifique (France)
Dinh-Hoan Trinh, Univ. de Lorraine, CNRS, Ctr. National de la Recherche Scientifique (France)
Victor Loschenov , A. M. Prokhorov General Physics Institute of the Russian Academy of Sciences (Russian Federation)


Published in SPIE Proceedings Vol. 10677:
Unconventional Optical Imaging
Corinne Fournier; Marc P. Georges; Gabriel Popescu, Editor(s)

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