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Proceedings Paper

In-vivo interleukin-1-alpha induction following chlorin-e6 photodynamic therapy in Balb/c mice
Author(s): Piotr P. Ziolkowski; Krzysztof Symonowicz; Jerzy Milach
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Paper Abstract

Photodynamic therapy may induce in in-vivo conditions the cytokine Interleukin-1-alpha in Balb/c mice. The sensitizer, i.e. chlorin e6, in the doses 2.5 and 5.0 mg/kg of body weight followed by light treatment with doses 50 and 100 J/ resulted in the increase in serum levels of the cytokine. The levels of Interleukin-1-alpha have been determined at different time points using enzyme-linked immunosorbent assay (ELISA). These levels in control animals did not exceed the mean value of 15 pg/ml, whereas in photodynamically treated mice the levels were almost 3 - 4 times higher. The entire experiment has been carried out on healthy animals.

Paper Details

Date Published: 31 January 1996
PDF: 8 pages
Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); doi: 10.1117/12.230989
Show Author Affiliations
Piotr P. Ziolkowski, Medical Univ. of Wroclaw (Poland)
Krzysztof Symonowicz, Medical Univ. of Wroclaw (Poland)
Jerzy Milach, Medical Univ. of Wroclaw (Poland)

Published in SPIE Proceedings Vol. 2625:
Photochemotherapy: Photodynamic Therapy and Other Modalities
Benjamin Ehrenberg; Giulio Jori; Johan Moan, Editor(s)

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