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Proceedings Paper

Enhancement of the efficiency of photodynamic therapy by combination with the microtubule inhibitor vincristine
Author(s): Li Wei Ma; Kristian Berg; Havard E. Danielsen; Vladimir Iani; Johan Moan
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Paper Abstract

Combination effects of photodynamic therapy (PDT) with meso-tetra (di-adjacent- sulfonatophenyl) porphine (TPPS2a) and the microtubule (MT) inhibitor, vincristine (VCR), were studied in the CaD2 mouse tumor model in mice. A synergistic effect was found when VCR, at an almost nontoxic dose (1 mg/kg), was injected i.p. into the mice 6 hr before PDT. The data on mitotic index show a 4 - 5 fold accumulation of the cells in mitosis 6 hr after injection of VCR into the mice. Cell cycle and ploidy distributions in tumor tissues were determined by means of image analysis with measurement of integrated optical density after Feulgen reaction on monolayers. Ploidy distribution of the tumors was not significantly changed 6 and 12 hr after administration of VCR only, while an increasing aneuploidy was observed 24 and 48 hr after VCR treatment. No prominent changes of the cell cycle and ploidy distributions were found in the tumor tissues after PDT or PDT combined with VCR.

Paper Details

Date Published: 31 January 1996
PDF: 9 pages
Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); doi: 10.1117/12.230984
Show Author Affiliations
Li Wei Ma, Institute for Cancer Research (Norway)
Kristian Berg, Institute for Cancer Research (Norway)
Havard E. Danielsen, Institute for Cancer Research (Norway)
Vladimir Iani, Institute for Cancer Research (Norway)
Johan Moan, Institute for Cancer Research (Norway)


Published in SPIE Proceedings Vol. 2625:
Photochemotherapy: Photodynamic Therapy and Other Modalities
Benjamin Ehrenberg; Giulio Jori; Johan Moan, Editor(s)

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