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Proceedings Paper

Silicon naphthalocyanines derivatives: delivery systems as modulators of pharmacokinetics and photodynamic therapy (PDT) outcomes
Author(s): Martha Kreimer-Birnbaum; Maria M. Zuk; Boris D. Rihter; Malcolm E. Kenney; Michael A. J. Rodgers
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Paper Abstract

Photodynamic therapy of neoplastic tissues is a new treatment modality that combines the in- vivo administration of a photosensitizer followed by its excitation with visible light, which leads to a photochemical reaction and tissue destruction. Naphthalocyanine derivatives are a class of second-generation photosensitizers that have excellent prospects as photodynamic therapeutic agents. Relevant to these types of applications are their photochemical properties, their tumor-localizing abilities, and their ability to elicit photodynamic responses. Bis(di- isobutyloctadecylsiloxy)silicon 2,3-naphthalocyanine (isoBOSINC) illustrates some of the above promising photoproperties: absorption in the red at 776 nm with an extinction coefficient greater than 105 M-1 cm-1, a triplet state lifetime of 331 microseconds and singlet oxygen yields of approximately 0.20. Due to their high degree of hydrophobicity, metallonaphthalocyanines require a variety of approaches before they can be administered to cells in vitro or injected in vivo. One approach is the selection of solubilizing agents or vehicles such as a solution of Tween 80 in saline or emulsions of Cremophor EL in saline. This paper describes studies in (a) drug uptake by tumors and other tissues as a function of isoBOSINC's dose; (b) drug levels in normal versus tumor-bearing rats; (c) in-vitro photostability of isoBOSINC; (d) effects of delivery systems on photosensitizer tissue levels and pharmacokinetics, and PDT outcome.

Paper Details

Date Published: 31 January 1996
PDF: 12 pages
Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); doi: 10.1117/12.230976
Show Author Affiliations
Martha Kreimer-Birnbaum, St. Vincent Medical Ctr. and Medical College of Ohio (United States)
Maria M. Zuk, St. Vincent Medical Ctr. and Bowling Green State Univ. (United States)
Boris D. Rihter, Case Western Reserve Univ. (United States)
Malcolm E. Kenney, Case Western Reserve Univ. (United States)
Michael A. J. Rodgers, Bowling Green State Univ. (United States)

Published in SPIE Proceedings Vol. 2625:
Photochemotherapy: Photodynamic Therapy and Other Modalities
Benjamin Ehrenberg; Giulio Jori; Johan Moan, Editor(s)

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